Unraveling the mystery of white matter in depression: A translational perspective on recent advances.

ABSTRACT:

Background

Numerous cortical and subcortical structures have been studied extensively concerning alterations of their integrity as well as their neurotransmitters in depression. However, connections between these structures have received considerably less attention.

Objective

This systematic review presents results from recent neuroimaging as well as neuropathologic studies conducted on humans and other mammals. It aims to provide evidence for impaired white matter integrity in individuals expressing a depressive phenotype.

Methods

A systematic database search in accordance with the PRISMA guidelines was conducted to identify imaging and postmortem studies conducted on humans with a diagnosis of major depressive disorder, as well as on rodents and primates subjected t

SUBMITTER: Abraham M 

PROVIDER: S-EPMC9304855 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature