Th1-Dominant CD4⁺ T Cells Orchestrate Endogenous Systematic Antitumor Immune Memory After Cryo-Thermal Therapy.

ABSTRACT: Recent studies suggest that highly activated, polyfunctional CD4⁺ T cells are incredibly effective in strengthening and sustaining overall host antitumor immunity, promoting tumor-specific CD4⁺ T-cell responses and effectively enhancing antitumor immunity by immunotherapy. Previously, we developed a novel cryo-thermal therapy for local tumor ablation and achieved long-term survival rates in several tumor models. It was discovered that cryo-thermal therapy remodeled the tumor microenvironment and induced an antigen-specific CD4⁺ T-cell response, which mediated stronger antitumor immunity in vivo. In this study, the phenotype of bulk T cells in spleen was analyzed by flow cytometry after cryo-thermal therapy and both CD4⁺ Th1 and CD8^+</

SUBMITTER: Peng P 

PROVIDER: S-EPMC9304863 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature