Clonal Dissemination of Aeromonas hydrophila With Binary Carriage of bla _KPC-2-Bearing Plasmids in a Chinese Hospital.

ABSTRACT: Dissemination of the Klebsiella pneumoniae carbapenemase (KPC)-encoding gene among Enterobacterales is common but relatively rare in Aeromonas spp. In this study, we characterized two KPC-2-producing Aeromonas hydrophila strains (Ah2101 and Ah2111), each isolated from a patient in different intensive care units (ICUs) of a Chinese hospital. Whole-genome sequencing (WGS) revealed simultaneous carriage of the bla _KPC-2 and imiH genes, both of which encode high-level carbapenem resistance in these two A. hydrophila isolates. The two isolates were shown to be clonally related and each isolate harbored two distinguishable bla _KPC-2-bearing plasmids, only one of which was transferrable to A. hydrophila, but not Esch

SUBMITTER: Xu Z 

PROVIDER: S-EPMC9304888 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature