Temporal Dynamic Analysis of Alternative Splicing During Embryonic Development in Zebrafish.

ABSTRACT: Alternative splicing is pervasive in mammalian genomes and involved in embryo development, whereas research on crosstalk of alternative splicing and embryo development was largely restricted to mouse and human and the alternative splicing regulation during embryogenesis in zebrafish remained unclear. We constructed the alternative splicing atlas at 18 time-course stages covering maternal-to-zygotic transition, gastrulation, somitogenesis, pharyngula stages, and post-fertilization in zebrafish. The differential alternative splicing events between different developmental stages were detected. The results indicated that abundance alternative splicing and differential alternative splicing events are dynamically changed and remarkably abundant during the maternal-to-zygotic transition process.

SUBMITTER: Liu Z 

PROVIDER: S-EPMC9304896 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature