Effect of Oropharyngeal Administration of Colostrum in Premature Newborns ≤32 Weeks of Gestation on the Immune Response and Neonatal Morbidity: A Double-Blind Randomized Clinical Trial.

ABSTRACT:

Introduction

The mother's colostrum carries immunological components, such as cytokines and immunoglobulins (Igs), derived from the maternal circulation with bacteriostatic properties.

Objective

The objective of this study was to evaluate the effect of oropharyngeal administration of colostrum (OPAC) vs. placebo in the first 4 days of life in premature newborns ≤32 weeks of gestation on serum Ig concentration, neonatal morbidity, and total days of hospitalization.

Hypothesis

The OPAC increases serum Igs and decreases morbidity and total days of hospitalization.

Materials and methods

A double-blind randomized controlled trial was carried out. Participants were randomly assigned to one of the two groups, namely, group 1: placebo (P) (n = 50) and group 2: c

SUBMITTER: Romero-Maldonado S 

PROVIDER: S-EPMC9304973 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature