Translational Approaches for Brain Delivery of Biologics via Cerebrospinal Fluid.

ABSTRACT: Delivery of biologics via cerebrospinal fluid (CSF) has demonstrated potential to access the tissues of the central nervous system (CNS) by circumventing the blood-brain barrier and blood-CSF barrier. Developing an effective CSF drug delivery strategy requires optimization of multiple parameters, including choice of CSF access point, delivery device technology, and delivery kinetics to achieve effective therapeutic concentrations in the target brain region, whereas also considering the biologic modality, mechanism of action, disease indication, and patient population. This review discusses key preclinical and clinical examples of CSF delivery for different biologic modalities (antibodies, nucleic acid-based therapeutics, and gene therapy) to the brain via CSF or CNS access routes (intracer

SUBMITTER: Sadekar SS 

PROVIDER: S-EPMC9305158 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature