Primary age-related tauopathy in a Finnish population-based study of the oldest old (Vantaa 85+).

ABSTRACT:

Aims

Few studies have investigated primary age-related tauopathy (PART) in a population-based setting. Here, we assessed its prevalence, genetic background, comorbidities and features of cognitive decline in an unselected elderly population.

Methods

The population-based Vantaa 85+ study includes all 601 inhabitants of Vantaa aged ≥ 85 years in 1991. Neuropathological assessment was possible in 301. Dementia (DSM IIIR criteria) and Mini-Mental State Examination (MMSE) scores were assessed at the baseline of the study and follow-ups. PART subjects were identified according to the criteria by Crary et al and were compared with subjects with mild and severe Alzheimer's disease (AD) neuropathological changes. The effects of other neuropathologies were taken into account using mul

SUBMITTER: Savola S 

PROVIDER: S-EPMC9305229 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature