Model to predict on-treatment restoration of functional HBV-specific CD8⁺ cell response foresees off-treatment HBV control in eAg-negative chronic hepatitis B.

ABSTRACT:

Background

Hepatitis B virus (HBV)-specific CD8⁺ cell response restoration during nucleos(t)ide analogue (NUC) treatment could lead to off-treatment HBV control in e-antigen-negative chronic hepatitis B (CHBe(-)).

Aim

To predict this response with variables involved in T-cell exhaustion for use as a treatment stopping tool.

Methods

In NUC-treated CHBe(-) patients, we considered a functional response in cases with HBV-specific CD8⁺ cells against core and polymerase HBV epitopes able to proliferate and secrete type I cytokines after antigen encounter. We performed a logistic regression model (LRM) to predict the likelihood of developing this response, based on patient age (subrogate of infection length), HBsAg level, NUC therapy starting point and

SUBMITTER: Pena-Asensio J 

PROVIDER: S-EPMC9305412 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature