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Wavelength-Orthogonal Stiffening of Hydrogel Networks with Visible Light.

ABSTRACT: Herein, we introduce the wavelength-orthogonal crosslinking of hydrogel networks using two red-shifted chromophores, i.e. acrylpyerene (AP, λ_activation =410-490 nm) and styrylpyrido[2,3-b]pyrazine (SPP, λ_activation =400-550 nm), able to undergo [2+2] photocycloaddition in the visible-light regime. The photoreactivity of the SPP moiety is pH-dependent, whereby an acidic environment inhibits the cycloaddition. By employing a spiropyran-based photoacid generator with suitable absorption wavelength, we are able to restrict the activation wavelength of the SPP moiety to the green light region (λ_activation =520-550 nm), enabling wavelength-orthogonal activation of the AP group. Our wavelength-orthogonal photochemical system was successfully applied in the design of hydrogels whose stiffness can be tuned independently by either green or blue light.

SUBMITTER: Truong VX

PROVIDER: S-EPMC9305448 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Wavelength-Orthogonal Stiffening of Hydrogel Networks with Visible Light.

Truong Vinh X VX Bachmann Julian J Unterreiner Andreas-Neil AN Blinco James P JP Barner-Kowollik Christopher C

Angewandte Chemie (International ed. in English) 20220215 15

Herein, we introduce the wavelength-orthogonal crosslinking of hydrogel networks using two red-shifted chromophores, i.e. acrylpyerene (AP, λ<sub>activation</sub> =410-490 nm) and styrylpyrido[2,3-b]pyrazine (SPP, λ<sub>activation</sub> =400-550 nm), able to undergo [2+2] photocycloaddition in the visible-light regime. The photoreactivity of the SPP moiety is pH-dependent, whereby an acidic environment inhibits the cycloaddition. By employing a spiropyran-based photoacid generator with suitable ...[more]

PMID: 35029002

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