Repurposing of Trimetazidine for amyotrophic lateral sclerosis: A study in SOD1^G93A mice.

ABSTRACT:

Background and purpose

Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the degeneration of upper and lower motor neurons, progressive wasting and paralysis of voluntary muscles and is currently incurable. Although considered to be a pure motor neuron disease, increasing evidence indicates that the sole protection of motor neurons by a single targeted drug is not sufficient to improve the pathological phenotype. We therefore evaluated the therapeutic potential of the multi-target drug used to treatment of coronary artery disease, trimetazidine, in SOD1^G93A mice.

Experimental approach

As a metabolic modulator, trimetazidine improves glucose metabolism. Furthermore, trimetazidine enhances mitochondrial metabolism and promotes nerve r

SUBMITTER: Scaricamazza S 

PROVIDER: S-EPMC9305494 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature