Screening for atrial fibrillation to prevent stroke: a meta-analysis.

ABSTRACT:

Aims

We aimed to summarize existing evidence from published randomized trials that assessed atrial fibrillation (AF) screening for stroke prevention.

Methods and results

We searched MEDLINE for randomized trials that enrolled patients without known AF, screened for AF using electrocardiogram-based methods, and reported stroke outcomes. For this analysis, we excluded studies that focused on post-stroke populations. We combined data using a random-effects model and performed trial sequential meta-analysis using an O'Brien-Fleming alpha-spending function.We identified four randomized clinical trials with a total of 35 836 participants. The populations, screening intervention, and definition of stroke varied markedly. As compared with no screening, AF screening was associated wi

SUBMITTER: McIntyre WF 

PROVIDER: S-EPMC9305505 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature