Dataset Information

Systematic review with meta-analysis: the accuracy of serological tests to support the diagnosis of coeliac disease.

ABSTRACT:

Background

There is growing support for a biopsy avoidant approach to diagnose coeliac disease in both children and adults, using a serological diagnosis instead.

Aims

To assess the diagnostic accuracy of serological tests for coeliac disease in adults and children.

Methods

Seven electronic databases were searched between January 1990 and August 2020. Eligible diagnostic studies evaluated the accuracy of serological tests for coeliac disease against duodenal biopsy. Risk of bias assessment was performed using QUADAS-2. Bivariate random-effects meta-analyses were used to estimate serology sensitivity and specificity at the most commonly reported thresholds.