Genetic Pathways Associated With Sleep Problems in Children With Autism Spectrum Disorder.

ABSTRACT:

Aims

Children on the autism spectrum are more likely to have sleep problems than non-autistic children. Sleep disturbance may exacerbate emotional and behavioral problems of children on the autism spectrum. A better understanding of the biological mechanisms underlying sleep disturbance provide clues to better management for this co-morbid condition in autism. The goal of the current study is to identify genetic variants associated with sleep disturbance and melatonin levels in autistic children.

Methods

A total of 969 children on the autism spectrum were genotyped using the Global Screening Array v1 or Global Screening Array v2. Sleep problems were assessed using the Children's Sleep Habits Questionnaire (CSHQ). Melatonin levels were measured using the urine samples of 219

SUBMITTER: Lin PI 

PROVIDER: S-EPMC9305657 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature