Immunomodulatory therapy for the management of critically ill patients with COVID-19: A narrative review.

ABSTRACT:

Background

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic. Understanding the physiological and immunological processes underlying the clinical manifestations of COVID-19 is vital for the identification and rational design of effective therapies.

Aim

To describe the interaction of SARS-CoV-2 with the immune system and the subsequent contribution of hyperinflammation and abnormal immune responses to disease progression together with a complete narrative review of the different immunoadjuvant treatments used so far in COVID-19 and their indication in severe and life-threatening subsets.

Methods

A comprehensive literature search was developed. Authors reviewed the selected man

SUBMITTER: Andaluz-Ojeda D 

PROVIDER: S-EPMC9305685 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature