Machine Learning Techniques for the Diagnosis of Schizophrenia Based on Event-Related Potentials.

ABSTRACT:

Antecedent

The event-related potential (ERP) components P300 and mismatch negativity (MMN) have been linked to cognitive deficits in patients with schizophrenia. The diagnosis of schizophrenia could be improved by applying machine learning procedures to these objective neurophysiological biomarkers. Several studies have attempted to achieve this goal, but no study has examined Multiple Kernel Learning (MKL) classifiers. This algorithm finds optimally a combination of kernel functions, integrating them in a meaningful manner, and thus could improve diagnosis.

Objective

This study aimed to examine the efficacy of the MKL classifier and the Boruta feature selection method for schizophrenia patients (SZ) and healthy controls (HC) single-subject classification.

Methods

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SUBMITTER: Santos Febles E 

PROVIDER: S-EPMC9305700 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature