Tracking Molecular Diffusion across Biomaterials' Interfaces Using Stimulated Raman Scattering.

ABSTRACT: The determination of molecular diffusion across biomaterial interfaces, including those involving hydrogels and tissues remains important, underpinning the understanding of a broad range of processes including, for example, drug delivery. Current techniques using Raman spectroscopy have previously been established as a method to quantify diffusion coefficients, although when using spontaneous Raman spectroscopy, the signal can be weak and dominated by interferences such as background fluorescence (including biological autofluoresence). To overcome these issues, we demonstrate the use of the stimulated Raman scattering technique to obtain measurements in soft tissue samples that have good signal-to-noise ratios and are largely free from fluorescence interference. As a model illustration of

SUBMITTER: Cui H 

PROVIDER: S-EPMC9305705 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature