Development of an In Vitro Biomimetic Peripheral Neurovascular Platform.

ABSTRACT: Nerves and blood vessels are present in most organs and are indispensable for their function and homeostasis. Within these organs, neurovascular (NV) tissue forms congruent patterns and establishes vital interactions. Several human pathologies, including diabetes type II, produce NV disruptions with serious consequences that are complicated to study using animal models. Complex in vitro organ platforms, with neural and vascular supply, allow the investigation of such interactions, whether in a normal or pathological context, in an affordable, simple, and direct manner. To date, a few in vitro models contain NV tissue, and most strategies report models with nonbiomimetic representations of the native environment. To this end, we have established here an NV platform that contains mature vasc

SUBMITTER: Malheiro A 

PROVIDER: S-EPMC9305708 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature