Differences in thrombin and plasmin generation potential between East African and Western European adults: The role of genetic and non-genetic factors.

ABSTRACT:

Background

Geographic variability in coagulation across populations and their determinants are poorly understood.

Objective

To compare thrombin (TG) and plasmin (PG) generation parameters between healthy Tanzanian and Dutch individuals, and to study associations with inflammation and different genetic, host and environmental factors.

Methods

TG and PG parameters were measured in 313 Tanzanians of African descent living in Tanzania and 392 Dutch of European descent living in the Netherlands and related to results of a dietary questionnaire, circulating inflammatory markers, genotyping, and plasma metabolomics.

Results

Tanzanians exhibited an enhanced TG and PG capacity, compared to Dutch participants. A higher proportion of Tanzanians had a TG value in the upper

SUBMITTER: Temba GS 

PROVIDER: S-EPMC9305795 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature