Risk of major depressive disorder in adolescent and young adult cancer patients in Japan.

ABSTRACT:

Objective

To estimate the risk of major depressive disorder (MDD) in adolescent and young adult (AYA) patients with cancer in Japan and identify risk factors for MDD among these patients.

Methods

This was a matched cohort study using a large claims database in Japan. Included patients were aged 15-39 years, newly diagnosed with cancer during 2012-2017 and assessable for a follow-up period of 12 months. Kaplan-Meier estimates and Cox proportional hazards models were used to calculate hazard ratios (HR) and 95% confidence intervals (CI) for MDD in the AYA patients with cancer versus age-, sex- and working status-matched cancer-free controls. A subgroups analysis of the AYA patients with cancer was performed to explore MDD risk factors.

Results

A total of 3559 AYA patien

SUBMITTER: Akechi T 

PROVIDER: S-EPMC9305902 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature