Sensorimotor integration within the primary motor cortex by selective nerve fascicle stimulation.

ABSTRACT: The integration of sensory inputs in the motor cortex is crucial for dexterous movement. We recently demonstrated that a closed-loop control based on the feedback provided through intraneural multichannel electrodes implanted in the median and ulnar nerves of a participant with upper limb amputation improved manipulation skills and increased prosthesis embodiment. Here we assessed, in the same participant, whether and how selective intraneural sensory stimulation also elicits a measurable cortical activation and affects sensorimotor cortical circuits. After estimating the activation of the primary somatosensory cortex evoked by intraneural stimulation, sensorimotor integration was investigated by testing the inhibition of primary motor cortex (M1) output to transcranial magnetic stimulatio

SUBMITTER: Ranieri F 

PROVIDER: S-EPMC9305922 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature