Whole-brain mapping of mouse CSF flow via HEAP-METRIC phase-contrast MRI.

ABSTRACT:

Purpose

CSF plays important roles in clearing brain waste and homeostasis. However, mapping whole-brain CSF flow in the rodents is difficult, primarily due to its assumed very low velocity. Therefore, we aimed to develop a novel phase-contrast MRI method to map whole-brain CSF flow in the mouse brain.

Methods

A novel generalized Hadamard encoding-based multi-band scheme (dubbed HEAP-METRIC, Hadamard Encoding APproach of Multi-band Excitation for short TR Imaging aCcelerating) using complex Hadamard matrix was developed and incorporated into conventional phase contrast (PC)-MRI to significantly increase SNR.

Results

Slow flow phantom imaging validated HEAP-METRIC PC-MRI's ability to achieve fast and accurate mapping of slow flow velocities (~10²  µm/s). With

SUBMITTER: Li J 

PROVIDER: S-EPMC9305925 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature