Toward Bifunctional Chelators for Thallium-201 for Use in Nuclear Medicine.

ABSTRACT: Auger electron therapy exploits the cytotoxicity of low-energy electrons emitted during radioactive decay that travel very short distances (typically <1 μm). ²⁰¹Tl, with a half-life of 73 h, emits ∼37 Auger and other secondary electrons per decay and can be tracked in vivo as its gamma emissions enable SPECT imaging. Despite the useful nuclear properties of ²⁰¹Tl, satisfactory bifunctional chelators to incorporate it into bioconjugates for molecular targeting have not been developed. H₄pypa, H₅decapa, H₄neunpa-NH₂, and H₄noneunpa are multidentate N- and O-donor chelators that have previously been shown to have high affinity for ¹¹¹In, ¹⁷⁷Lu, and ⁸⁹Zr. Herein, we report the s

SUBMITTER: Rigby A 

PROVIDER: S-EPMC9305974 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature