Relationship of caffeine regimen with osteopenia of prematurity in preterm neonates: a cohort retrospective study.

ABSTRACT:

Background

Caffeine is a routinely prescribed pharmacological active compound in neonatal intensive care units (NICU) for treating apnea of prematurity (AOP), which also decreases the risk of bronchopulmonary dysplasia and cerebral palsy in neonates. Caffeine-induced excessive calcium loss can promote the development of metabolic bone disease (MBD) in preterm neonates. This study aimed to evaluate the effect of the caffeine regimen on the development of osteopenia of prematurity (OOP), using serum alkaline phosphatase (serum-ALP) concentrations as a surrogate marker at the 4^th week of life.

Methods

This retrospective cohort study was conducted including neonates of < 32 weeks gestational age (GA) and birth weight < 1500 g, admitted to NICU from April-2017 to Decem

SUBMITTER: Kumar M 

PROVIDER: S-EPMC9306044 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature