Expression of voltage-gated Ca²⁺ channels, Insp₃Rs, and RyRs in the immature mouse ovary.

ABSTRACT:

Background

The postnatal mammalian ovary undergoes a series of changes to ensure the maturation of sufficient follicles to support ovulation and fecundation over the reproductive life. It is well known that intracellular [Ca²⁺]_i signals are necessary for ovulation, fertilization, and egg activation. However, we lack detailed knowledge of the molecular identity, cellular distribution, and functional role of Ca²⁺ channels expressed during folliculogenesis. In the neonatal period, ovarian maturation is controlled by protein growth factors released from the oocyte and granulosa cells. Conversely, during the early infantile period, maturation becomes gonadotropin-dependent and is controlled by granulosa and theca cells. The significance of intracellular

SUBMITTER: Bahena-Alvarez D 

PROVIDER: S-EPMC9306205 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature