Estimating transmission dynamics of SARS-CoV-2 at different intraspatial levels in an institutional outbreak.

ABSTRACT:

Introduction

Large, localised outbreaks of COVID-19 have been repeatedly reported in high-density residential institutions. Understanding the transmission dynamics will inform outbreak response and the design of living environments that are more resilient to future outbreaks.

Methods

We developed an individual-based, multilevel transmission dynamics model using case, serology and symptom data from a 60-day cluster randomised trial of prophylaxes in a densely populated foreign worker dormitory in Singapore. Using Bayesian data augmentation, we estimated the basic reproduction number and the contribution that within-room, between-level and across-block transmission made to it, and the prevalence of infection over the study period across different spatial levels. We then simula

SUBMITTER: Jin S 

PROVIDER: S-EPMC9306265 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature