DNA-PKcs: A Targetable Protumorigenic Protein Kinase.

ABSTRACT: DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a pleiotropic protein kinase that plays critical roles in cellular processes fundamental to cancer. DNA-PKcs expression and activity are frequently deregulated in multiple hematologic and solid tumors and have been tightly linked to poor outcome. Given the potentially influential role of DNA-PKcs in cancer development and progression, therapeutic targeting of this kinase is being tested in preclinical and clinical settings. This review summarizes the latest advances in the field, providing a comprehensive discussion of DNA-PKcs functions in cancer and an update on the clinical assessment of DNA-PK inhibitors in cancer therapy.

SUBMITTER: Dylgjeri E 

PROVIDER: S-EPMC9306356 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature