Comparative survival of environmental and clinical Mycobacterium abscessus isolates in a variety of diverse host cells.

ABSTRACT:

Aims

Mycobacterium abscessus subsp. abscessus (MABS) is an emerging, opportunistic pathogen found globally in freshwater biofilms and soil. Typically, isolates are treated as a uniform group of organisms and very little is known about their comparative survival in healthy host cells. We posit that environmentally- and clinically derived isolates, show differential infectivity in immune cells and resistance to innate defenses.

Methods and results

Six MABS isolates were tested including three water biofilm/soil and three sputum-derived isolates. A clinical MABS type strain and an environmental isolate of Arthrobacter were also included. MABS counts were significantly higher compared to Arthrobacter after co-culture with Acanthamoeba lenticulata, BEAS-2B epithelial cells, alveo

SUBMITTER: Vang CK 

PROVIDER: S-EPMC9306708 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature