Altered Cholinergic Innervation in De Novo Parkinson's Disease with and Without Cognitive Impairment.

ABSTRACT:

Background

Altered cholinergic innervation plays a putative role in cognitive impairment in Parkinson's disease (PD) at least in advanced stages. Identification of the relationship between cognitive impairment and cholinergic innervation early in the disease will provide better insight into disease prognosis and possible early intervention.

Objective

The aim was to assess regional cholinergic innervation status in de novo patients with PD, with and without cognitive impairment.

Methods

Fifty-seven newly diagnosed, treatment-naive, PD patients (32 men, mean age 64.6 ± 8.2 years) and 10 healthy controls (5 men, mean age 54.6 ± 6.0 years) were included. All participants underwent cholinergic [¹⁸ F]fluoroethoxybenzovesamicol positron emission tomography and det

SUBMITTER: van der Zee S 

PROVIDER: S-EPMC9306739 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature