IL-17 serum level in patients with chronic mucocutaneous candidiasis disease.

ABSTRACT:

Background

Chronic mucocutaneous candidiasis (CMC) is defined by recurrent or persistent superficial infections involving nails, skin, and/or oral and genital mucosae. IL-17 promotes the recruitment, chemotaxis, and expansion of neutrophils and acts directly on keratinocytes and epithelial cells, driving the production of antimicrobial peptides, essential for the immune response against Candida.

Aim

To evaluate the serum level of IL-17 in a family affected by CMC restricted to the nails of the hands and feet.

Methods

Serum IL-17 was assayed on 16 patients (aged 21 ± 3.1 years) suffering from persistent onychomycosis caused by Candida and 18 healthy controls (aged 19 ± 2.7 years). Comparisons between groups were performed by Student's unpaired t-test. The level of sign

SUBMITTER: Chimenz R 

PROVIDER: S-EPMC9306849 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature