Ontology highlight
ABSTRACT:
SUBMITTER: Purins M
PROVIDER: S-EPMC9306854 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20220201 11
For the enantioselective diversification of a single starting material, a different chiral catalyst is usually required for each transformation. Herein, we extend the concept of catalytically formed chiral auxiliary from hydrogenation to the asymmetric cyclopropanation and epoxidation of tetra-substituted olefins, alleviating the need for different chiral catalysts in the alkene functionalization step. The chiral auxiliary is catalytically constructed from propargylic amines in a Pd-catalyzed en ...[more]