Ductal and acinar components of mixed prostatic adenocarcinoma frequently have a common clonal origin.

ABSTRACT:

Background

Ductal adenocarcinoma (DA) is an aggressive subtype of prostate cancer. It is most commonly seen in mixed tumors together with conventional acinar adenocarcinoma (AA). The genetic profile of DA and its clonal origin is not fully characterized.

Objective

To investigate whether DA represents a distinct genetic subtype and to investigate the somatic relationship between the ductal and acinar components of mixed cancers.

Design, setting, and participants

In 17 radical prostatectomy specimens ductal and acinar tumor components from the same tumor foci were dissected. DNA was extracted and genomic sequencing performed. After exclusion of two cases with low cell yield, 15 paired samples remained for analysis.

Results

In 12 of 15 cases a common somatic denom

SUBMITTER: Lindh C 

PROVIDER: S-EPMC9306900 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature