Influence of liver stiffness heterogeneity on staging fibrosis in patients with nonalcoholic fatty liver disease.

ABSTRACT:

Background and aims

Despite that hepatic fibrosis often affects the liver globally, spatial distribution can be heterogeneous. This study aimed to investigate the effect of liver stiffness (LS) heterogeneity on concordance between MR elastography (MRE)-based fibrosis staging and biopsy staging in patients with NAFLD.

Approach and results

We retrospectively evaluated data from 155 NAFLD patients who underwent liver biopsy and 3 Tesla MRE and undertook a retrospective validation study of 169 NAFLD patients at three hepatology centers. Heterogeneity of stiffness was assessed by measuring the range between minimum and maximum MRE-based LS measurement (LSM). Variability of LSM was defined as the stiffness range divided by the maximum stiffness value. The cohort was divided into t

SUBMITTER: Kawamura N 

PROVIDER: S-EPMC9307017 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature