Randomised controlled trial of nebulised gentamicin in children with bronchiectasis.

ABSTRACT:

Aim

Following trials of inhaled antibiotics in adults, this study investigates the efficacy of nebulised gentamicin to improve respiratory function in children with bronchiectasis.

Methods

This is a randomised, double-blind, placebo-controlled, crossover trial of 12-week nebulised placebo/gentamicin, 6-week washout, 12-week gentamicin/placebo. Participants were children (5-15 years) with bronchiectasis, chronic infection (any pathogen), and able to perform spirometry from a hospital bronchiectasis clinic. Primary outcomes were change in forced expiratory volume in 1 s (FEV₁ ) and hospitalisation days. Secondary outcomes included sputum bacterial density, sputum inflammatory markers, additional antibiotics and symptom severity. Analyses were on an intention-to-trea

SUBMITTER: Twiss J 

PROVIDER: S-EPMC9307025 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature