Persistent CAD activity in memory CD8⁺ T cells supports rRNA synthesis and ribosomal biogenesis required at rechallenge.

ABSTRACT: Memory CD8⁺ T cells are characterized by their ability to persist long after the initial antigen encounter and their capacity to generate a rapid recall response. Recent studies have identified a role for metabolic reprogramming and mitochondrial function in promoting the longevity of memory T cells. However, detailed mechanisms involved in promoting their rapid recall response are incompletely understood. Here, we identify a role for the initial and continued activation of the trifunctional rate-limiting enzyme of the de novo pyrimidine synthesis pathway CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) as critical in promoting the rapid recall response of previously activated CD8⁺ T cells. We found that CAD was rapidly phosphoryl

SUBMITTER: Claiborne MD 

PROVIDER: S-EPMC9307092 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature