Association of Hyponatremia on Mortality in Cryptococcal Meningitis: A Prospective Cohort.

ABSTRACT:

Background

Sodium abnormalities are frequent in central nervous system infections and may be caused by cerebral salt wasting, syndrome of inappropriate antidiuretic hormone secretion, or medication adverse events. In cryptococcal meningitis (CM), the prevalence of baseline hyponatremia and whether hyponatremia adversely impacts survival is unknown.

Methods

We conducted a secondary analysis of data from 2 randomized trials of human immunodeficiency virus-infected adult Ugandans with CM. We grouped serum sodium into 3 categories: <125, 125-129, and 130-145 mmol/L. We assessed whether baseline sodium abnormalities were associated with clinical characteristics and survival.

Results

Of 816 participants with CM, 741 (91%) had a baseline sodium measurement available: 121 (16

SUBMITTER: Tugume L 

PROVIDER: S-EPMC9307099 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature