MAVS Expression in Alveolar Macrophages Is Essential for Host Resistance against Aspergillus fumigatus.

ABSTRACT: Our recent data demonstrate a critical role of the RIG-I-like receptor family in regulating antifungal immunity against Aspergillus fumigatus in a murine model. However, the importance of this pathway in humans and the cell types that use this innate immune receptor family to detect A. fumigatus remain unresolved. In this study, using patients who underwent hematopoietic stem cell transplantation, we demonstrate that a polymorphism in human MAVS present in the donor genome was associated with the incidence of invasive pulmonary aspergillosis. Moreover, in a separate cohort of confirmed invasive pulmonary aspergillosis patients, polymorphisms in the IFIH1 gene alter the inflammatory response, including IFN-responsive chemokines. Returning to our murine model, we

SUBMITTER: Wang X 

PROVIDER: S-EPMC9307106 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature