Addition of terlipressin to norepinephrine in septic shock and effect of renal perfusion: a pilot study.

ABSTRACT:

Purpose

Terlipressin improves renal function in patients with septic shock. However, the mechanism remains unclear. Here, we aimed to evaluate the effects of terlipressin on renal perfusion in patients with septic shock.

Materials and methods

This pilot study enrolled patients with septic shock in the intensive care unit of the tertiary hospital from September 2019 to May 2020. We randomly assigned patients to terlipressin and usual care groups using a 1:1 ratio. Terlipressin was intravenously pumped at a rate of 1.3 μg/kg/hour for 24 h. We monitored renal perfusion using renal contrast-enhanced ultrasound (CEUS). The primary outcome was peak sonographic signal intensity (a renal perfusion parameter monitored by CEUS) at 24 h after enrollment.

Results

22 patients were

SUBMITTER: Wang J 

PROVIDER: S-EPMC9307113 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature