Hub Gene Screening Associated with Early Glaucoma: An Integrated Bioinformatics Analysis.

ABSTRACT:

Background

Primary open-angle glaucoma (POAG) is the most common type of glaucoma. The potential influence of some DEGs on the progression of POAG was still incomplete. In this study, we integrated transcriptome data with clinical data to investigate the relationship between them in POAG patients.

Methods

The gene expression profile (GSE27276) from Gene Expression Omnibus (GEO) was used to identify DEGs. The LIMMA package of R was used to identify the DEGs (Diboun et al., 2006). The adjusted P values (adj P value) were calculated instead to avoid the appearance of false-positive results. Genes with |log₂ fold change (FC)| larger than 1 and adj P value < 0.01 were taken as DEGs between PH and PC samples. GO (Gene Ontology) function and KEGG (Ky

SUBMITTER: Tian R 

PROVIDER: S-EPMC9307363 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature