Sound-based assembly of a microcapillary network in a saturn-like tumor model for drug testing.

ABSTRACT: The tumor microenvironment (TME), consisting of extracellular matrix, proteins, stromal cells, and a vascular system, is reported to have a key role in cancer progression and prognosis. Thereby, the interaction between the vascular network and tumor mass is an important feature of the TME since the anticancer agents which are delivered to the TME can trigger the vascular response and influence the therapeutic outcome of the treatment. To identify and develop new therapeutic strategies, 3D in vitro models that recapitulate the complexity of the TME are urgently needed. Among them, vascularized tumor models are a promising approach, allowing to target tumor angiogenesis and reduce tumor growth. By using sound patterning, cells can be condensed locally into highly reproducible patterns

SUBMITTER: Di Marzio N 

PROVIDER: S-EPMC9307464 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature