Genome-wide association study in minority children with asthma implicates DNAH5 in bronchodilator responsiveness.

ABSTRACT: Variability in response to short-acting β₂-agonists (e.g., albuterol) among patients with asthma from diverse racial/ethnic groups may contribute to asthma disparities. We sought to identify genetic variants associated with bronchodilator response (BDR) to identify potential mechanisms of drug response and risk factors for worse asthma outcomes. Genome-wide association studies of bronchodilator response (BDR) were performed using TOPMed Whole Genome Sequencing data of the Asthma Translational Genomic Collaboration (ATGC), which corresponded to 1136 Puerto Rican, 656 Mexican and 4337 African American patients with asthma. With the population-specific GWAS results, a trans-ethnic meta-analysis was performed to identify BDR-associated variants shared across the three populations. R

SUBMITTER: Joo J 

PROVIDER: S-EPMC9307508 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature