The metabolic stress response: Adaptation to acute-, repeated- and chronic challenges in mice.

ABSTRACT: There is a strong relationship between stress and metabolism. Because acute traumatic- and chronic stress events are often accompanied with metabolic pathophysiology, it is important to understand the details of the metabolic stress response. In this study we directly compared metabolic effects of acute stress with chronic repeated- and chronic unpredictable stress in mouse models. All types of adversities increased energy expenditure, chronic stress exposure decreased body weight gain, locomotor activity and differentially affected fuel utilization. During chronic exposure to variable stressors, carbohydrates were the predominant fuels, whereas fatty acids were catabolized in acutely and repeatedly restrained animals. Chronic exposure to variable stressors in unpredictable manner provoked

SUBMITTER: Kuti D 

PROVIDER: S-EPMC9307515 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature