Sex, gender, and retinoblastoma: analysis of 4351 patients from 153 countries.

ABSTRACT:

Objective

To investigate in a large global sample of patients with retinoblastoma whether sex predilection exists for this childhood eye cancer.

Methods

A cross-sectional analysis including 4351 treatment-naive retinoblastoma patients from 153 countries who presented to 278 treatment centers across the world in 2017. The sex ratio (male/female) in the sample was compared to the sex ratio at birth by means of a two-sided proportions test at global level, country economic grouping, continent, and for selected countries.

Results

For the entire sample, the mean retinoblastoma sex ratio, 1.20, was higher than the weighted global sex ratio at birth, 1.07 (p < 0.001). Analysis at economic grouping, continent, and country-level demonstrated differences in the sex ratio in the

SUBMITTER: Fabian ID 

PROVIDER: S-EPMC9307655 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature