A macroscopic link between interhemispheric tract myelination and cortico-cortical interactions during action reprogramming.

ABSTRACT: Myelination has been increasingly implicated in the function and dysfunction of the adult human brain. Although it is known that axon myelination shapes axon physiology in animal models, it is unclear whether a similar principle applies in the living human brain, and at the level of whole axon bundles in white matter tracts. Here, we hypothesised that in humans, cortico-cortical interactions between two brain areas may be shaped by the amount of myelin in the white matter tract connecting them. As a test bed for this hypothesis, we use a well-defined interhemispheric premotor-to-motor circuit. We combined TMS-derived physiological measures of cortico-cortical interactions during action reprogramming with multimodal myelin markers (MT, R1, R2* and FA), in a large cohort of healthy subjects.

SUBMITTER: Lazari A 

PROVIDER: S-EPMC9307658 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature