Dose-volume analysis of planned versus accumulated dose as a predictor for late gastrointestinal toxicity in men receiving radiotherapy for high-risk prostate cancer.

ABSTRACT:

Background and purpose

Significant dose deviations have been reported between planned (D_P) and accumulated (D_A) dose in prostate radiotherapy. This study aimed to develop multivariate analysis (MVA) models associating Grade 1 and 2 gastrointestinal (GI) toxicity with clinical and D_P or D_A dosimetric variables separately.

Materials and methods

Dose volume (DV) metrics were compared between D_A and D_P for 150 high-risk prostate cancer patients. MV models were generated from significant clinical and dosimetric variables (p < 0.05) at univariate level. Dose-based-region of interest (DB-ROI) metrics were included. Model performance was measured, and additional subgroup analysis were performed.

Results

Rectal

SUBMITTER: Ong ALK 

PROVIDER: S-EPMC9307677 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature