SARM1 deletion in parvalbumin neurons is associated with autism-like behaviors in mice.

ABSTRACT: Autism spectrum disorder (ASD), a group of neurodevelopmental disorder diseases, is characterized by social deficits, communication difficulties, and repetitive behaviors. Sterile alpha and TIR motif-containing 1 protein (SARM1) is known as an autism-associated protein and is enriched in brain tissue. Moreover, SARM1 knockdown mice exhibit autism-like behaviors. However, its specific mechanism in ASD pathogenesis remains unclear. Here we generated parvalbumin-positive interneurons (PVI)-specific conditional SARM1 knockout (SARM1^PV-CKO) mice. SARM1^PV-CKO male mice showed autism-like behaviors, such as mild social interaction deficits and repetitive behaviors. Moreover, we found that the expression level of parvalbumin was reduced in SARM1^PV-CKO male mice, to

SUBMITTER: Xiang L 

PROVIDER: S-EPMC9307765 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature