Toll-like Receptor 9 Promotes Initiation of Gastric Tumorigenesis by Augmenting Inflammation and Cellular Proliferation.

ABSTRACT:

Background & aims

Gastric cancer (GC) is strongly linked with chronic gastritis after Helicobacter pylori infection. Toll-like receptors (TLRs) are key innate immune pathogenic sensors that mediate chronic inflammatory and oncogenic responses. Here, we investigated the role of TLR9 in the pathogenesis of GC, including Helicobacter infection.

Methods

TLR9 gene expression was profiled in gastric tissues from GC and gastritis patients and from the spontaneous gp130^F/F GC mouse model and chronic H felis-infected wild-type (WT) mice. Gastric pathology was compared in gp130^F/F and H felis infection models with or without genetic ablation of Tlr9. The impact of Tlr9 targeting on signaling cascades implicated in inflammation and tumorigenesis (eg, nuclear facto

SUBMITTER: Tang K 

PROVIDER: S-EPMC9307956 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature