Soluble urokinase plasminogen activator receptor and decline in kidney function among patients without kidney disease.

ABSTRACT:

Background

Hospitalized patients are at an increased risk of developing kidney disease after discharge, often despite the absence of any clinical indicators during hospitalization. Soluble urokinase plasminogen activator receptor (suPAR) is a marker of systemic chronic inflammation that can be measured from routine blood samples. We determined whether elevated suPAR during hospitalization is associated with a decline in estimated glomerular filtration rate (eGFR) after discharge.

Methods

This was a retrospective longitudinal cohort study of patients without detectable kidney disease presenting to the emergency department on two separate occasions during a 3-year period. The association between suPAR and a decline in eGFR was assessed by linear mixed models for repeated measu

SUBMITTER: Iversen E 

PROVIDER: S-EPMC9308102 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature