Identification of human mitochondrial RNA cleavage sites and candidate RNA processing factors.

ABSTRACT:

Background

The human mitochondrial genome is transcribed as long strands of RNA containing multiple genes, which require post-transcriptional cleavage and processing to release functional gene products that play vital roles in cellular energy production. Despite knowledge implicating mitochondrial post-transcriptional processes in pathologies such as cancer, cardiovascular disease and diabetes, very little is known about the way their function varies on a human population level and what drives changes in these processes to ultimately influence disease risk. Here, we develop a method to detect and quantify mitochondrial RNA cleavage events from standard RNA sequencing data and apply this approach to human whole blood data from > 1000 samples across independent cohorts.

Results

SUBMITTER: Carbajosa G 

PROVIDER: S-EPMC9308231 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature