Analysis of gastric microbiome reveals three distinctive microbial communities associated with the occurrence of gastric cancer.

ABSTRACT:

Background

Gastric microbial dysbiosis were reported to be associated with gastric cancer (GC). This study aimed to explore the variation, diversity, and composition patterns of gastric bacteria in stages of gastric carcinogenesis based on the published datasets.

Methods

We conducted a gastric microbial analysis using 10 public datasets based on 16S rRNA sequencing, including 1270 gastric biopsies of 109 health control, 183 superficial gastritis (SG), 135 atrophic gastritis (AG), 124 intestinal metaplasia (IM), 94 intraepithelial neoplasia (IN), 344 GC, and 281 adjacent normal tissues. And QIIME2-pipeline, DESeq2, NetMoss2, vegan, igraph, and RandomForest were used for the data processing and analysis.

Results

We identified three gastric microbial communities among al

SUBMITTER: Liu D 

PROVIDER: S-EPMC9308235 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature