Sex differences in contextual pattern separation, neurogenesis, and functional connectivity within the limbic system.

ABSTRACT:

Background

Females are more likely to present with anxiety disorders such as post-traumatic stress disorder (PTSD) compared to males, which are associated with disrupted hippocampal integrity. Sex differences in the structure and function of hippocampus exist. Here, we examined sex differences in contextual pattern separation, functional connectivity, and activation of new neurons during fear memory.

Methods

Two-month-old male and female Sprague-Dawley rats were injected with the DNA synthesis markers, iododeoxyuridine (IdU) and chlorodeoxyuridine (CldU) 3 weeks and 4 weeks before perfusion, respectively. One week after CldU injection, the rats underwent a context discrimination task in which rats were placed in context A (shock) and context A' (no shock) every day for 12 da

SUBMITTER: Yagi S 

PROVIDER: S-EPMC9308289 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature